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the differential toxicity of AFB 1 , between species is thought to be due mainly to different levels of activity of xenobiotic-metabolizing enzymes

Mellman, I., Chen, D

Additionally, inflammatory cytokines such as TNF- and IL-6 activate JNK and IKK kinases, further promoting IRS-1 serine phosphorylation and creating a vicious cycle that perpetuates insulin signaling dysfunction (57)