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First, PK/PD tractability should be decisive, favoring OSCs with reproducible human or large-animal exposure biomarkers or stable synthetic derivatives

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2017;113(Pt B):60817

In PD, nNOS expression is upregulated in the substantia nigra (Eve et al., 1998), whereas microglial iNOS levels are elevated across multiple neurodegenerative disorders (Lowenstein and Padalko, 2004)