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These effects possibly result from its potential to inhibit or alter cytochrome P450 enzymes (CYP3A4, CYP2D6), leading to increased drug levels and overlapping side effects including gastrointestinal distress and myalgia

10.1016/j.jconrel.2006.10.015 J

Symptoms of Sleep Deprivation Almost all bodily systems are impacted by sleep deprivation, which can cause anything from minor exhaustion to severe emotional and cognitive problems

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The ARID1A gene, a tumor suppressor, encodes a key subunit of the SWI/SNF chromatin remodeling complex, which regulates gene expression by altering chromatin structure (112)