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In order to overcome the aforementioned limitations, the newly designed molecular biosensors should be able to enter a confined space to identify the target and should have a uniform and constant signal output when present in a nanoscale environment in exosomes

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270 In pancreatic adenocarcinoma, XBP1s promotes angiogenesis through VEGF-independent mechanisms, further underscoring its capacity to sustain tumor vascularization and growth

For the index PCR, a 25 L reaction containing amplicon PCR product, 0.5 L of Platinum SuperFi II DNA Polymerase, 1 SuperFi II Buffer (Thermo Fisher Scientific), and 0.5 M each of Nextera XT Index Kit v2 index primers (Illumina) was prepared