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A 2016 study published in Nature Scientific Reports showed that GHK-Cu had no cytotoxicity to human keratinocytes at concentrations up to 5,800 micromolar over 72 hours and did not induce inflammatory biomarkers

This intracellular mechanism differentiates it from peptides that stimulate systemic signaling cascades

As reviewed in the 2018 Pickart & Margolina review, both deliver copper to cells and trigger regenerative responses

The consensus is that GHK-Cu is safe compared to its alternatives

Injection site reactions Injection site reactions represent the second major category of adverse events with cagrilintide, and this is where the compound differs most dramatically from GLP-1 medications