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Moreover, given that the majority of COPD patients have two or more age-related comorbidities (cardiovascular diseases and others) and that the same pathways of cellular senescence appear to operate in many age-related diseases, it may be possible to treat them all at once (20, 96)

(download TIF Stratified analysis of the effect of L-Citrulline on aortic diastolic blood pressure according to BP status

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To have a better insight into the possible role of CEs in the aetiopathogenesis of RA, we have demonstrated that CE-modified DNA was highly recognized not only by SLE IgG [40, 37, 39] and cancer IgG [36] but also by RA IgG [38], pointing out the possible participation of modified DNA in the pathogenesis of various autoimmune diseases including RA, as it has been reported that CE-modified DNA bases cause DNA strand breakage and adduct formation in vivo and in vitro [7]