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Xiao, Y

On a molecular level, this may also occur through mitochondrial dysfunction associated with decreased fat degradation due to PTM-mediated suppression of the enzymes in -oxidation [103, 211], upregulated immune cell infiltrations, protein adducts, lipid peroxidatifon, and DNA damage [190].Alcohol-mediated ROS and RNS can also downregulate -oxidation activity by inhibiting peroxisome proliferator-activated receptor- (PPAR-) and a lipid catabolism regulator named AMP-activated protein kinase (AMPK) [9, 213] while upregulating sterol regulatory binding protein-1 (SREBP-1) to increase hepatic fatty acid and cholesterol biosynthesis [9, 213]

These ERKS regulate numerous cellular processes, including cell proliferation, differentiation, and survival

Yudkoff M, Nissim I, Hertz L, Pleasure D, Ereciska M

C.MagyarC.BraasD.et al