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BioRXiv September 28, 2024:2024.09.26.614592

3b and c)

A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide

Compound extraction from tissue and plasma For Th-2-31, extraction from plasma was performed by adding 900 L acetonitrile to 100 L plasma, sonicating to mix, and incubating on ice for 2 h for optimal extraction

Then Lilly came along with #tirzepatide, a dual GLP-1 and GIP agonist, a molecule that didnt just improve glucose control but delivered an average 20% weight loss in clinical trials, compared to roughly 15% with Wegovy