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Despite being effective in blocking the conversion of DOPA to melanin, hydroquinone monotherapy has moderate effectiveness on hyperpigmentation [76, 77] and is responsible for numerous side effects such as mild erythema, burning sensation, dryness, pruritus, and scaling, making it prohibited for use in cosmetics in a majority of countries [77,78,79,80]

Choi SY, Piao ZH, Jin L, Kim JH, Kim GR, Ryu Y, Lin MQ, Kim H-S, Kee HJ, Jeong MH

Observational studies examining association of one-carbon metabolism nutrients status with risk of DM DM, diabetes mellitus

The color of our hair is created by the pigment-producing cells, called melanocytes, located in each hair follicle

doi: 10.1146/annurev.pathol.4.110807.092135 77