glutathione peroxidase selenium cofactor PRDX6 dictates ferroptosis sensitivity by directing cellular utilization: Molecular Cell and PQQ Selenium Metabolism and Biosynthesis of

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doi: 10.1016/j.trecan.2023.02.001 7 JiangXStockwellBRConradM

Lipoxygenases generate highly reactive peroxidation products of unsaturated fatty acids prone to further lipid peroxidation and GPX4 reduces lipid peroxidation products in membranes to stable hydroxyl-derivatives ( Gpx4 -knockout mice are phenotypically characterized by ineffective erythropoiesis ( The Role of GSH Depletion and GPX4 in Ferroptosis Ferroptosis has recently emerged as a new cell death modality

Correlating longitudinal multi-omics data from large, well-annotated patient cohorts with clinical outcomes will thus enable accurate patient stratification, guide therapeutic decision-making, and increase the success rate of clinical trials

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