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doi: 10.1097/GOX.0000000000002843

This is critical because droplet size determines where in the nasal cavity the drug deposits: droplets in the appropriate size range (typically 30200 m for nasal sprays) deposit in the nasal turbinates, where absorption occurs, while excessively small droplets may penetrate to the lower respiratory tract, and excessively large droplets may not clear the nasal vestibule

The flushing volume of the filter membrane should be optimized according to the characteristics of the sample

Its a preparation of sterile, non-pyrogenic water that contains a very specific addition: 0.9% benzyl alcohol (9mg/mL)

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