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avoidance recommended as a precaution Active malignancy: Pro-angiogenic mechanism warrants caution until more data is available History of hormone-sensitive cancers: Discuss thoroughly with your physician Severe coagulation disorders: Given vascular effects, clinical assessment required Patients on certain anticoagulants: Monitoring required

90 EGFR and its ligand EGF binding are the main causes of squamous cell metaplasia, and the growth of epithelial cells is most significant in smokers and COPD