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The mTORC1 inhibition by AMPK is accomplished by direct phosphorylation of the regulatory-associated protein of mTOR (Raptor) [264] and indirectly via activation of TSC2 [265, 266]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 124.Sanai N, Tien AC, Tovmasyan A, Chang YW, Margaryan T, Hendrickson K, et al

Nanocarriers, such as liposomes, polymers, inorganic nanoparticles, and hybrid nanoparticles, make therapies more effective by making drugs more stable, improving targeting accuracy and lowering side effects