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There are great variations in nuclear GSH concentration and its regulation mechanisms during the cell cycle since cells starting the proliferation phase have high levels of nuclear GSH, while resting cells have similar or lower GSH levels in the nucleus than in the cytoplasm (68, 72, 73)

Glutathione in the treatment of liver diseases: insights from clinical practice states, Judging on the basis of the evidence obtained from experimental research and previous clinical studies, GSH administration seems to be a promising strategy to recover oxidative stress-induced liver damages in alcoholic and non-alcoholic liver diseases. Glutathione supplementation is a critical part of a two-pronged approach to help the liver stay healthy and combat alcohol damage, which includes: Lifestyle choices: Limit alcohol and other toxins that you can control, like tobacco, as well as environmental stressors like pesticides and excessive UV rays

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PMID: 28121423 | doi:10.1021/acs.biochem.6b01215 Akar S et al