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Taken together, Lambert and colleagues concluded that acrolein and other 2-alkenals found in cigarette smoke can disrupt physiological regulation of gene expression by direct modification of the DNA-binding domain of a transcription factor and, as a consequence, they may cause immunosuppression upon exposure via cigarette smoke

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Brain Pathophysiology of PD Clinical researchers consider the pathological progress of PD in the brain initiates in the lower structures of the brainstem, followed by a caudal-to-rostral pattern as well as the involvement of the cortico-basal ganglia-cerebellar pathways