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Aronica L, Ordovas JM, Volkov A, Lamb JJ, Stone PM, Minich D, Leary M, Class M, Metti D, Larson IA, Contractor N, Eck B, Bland JS (2022) Genetic biomarkers of metabolic detoxification for personalized lifestyle medicine

The classic approach to address this issue by a medicinal chemist is often to use a prodrug approach by connecting a brain targeting ligand to a drug molecule to form a prodrug and the drug is released after the prodrug enters the brain

Then, the included or captured C60 can be released via the addition of an inclusion compotator as adamantane molecules, as illustrated in 270 The reversibility of the modified smart system can be utilized also for the fabrication and designing of other functional supramolecular hybrid materials

Images from H&E-stained sections were acquired using an Axiovert 200M microscope with an Axiocam HRc camera and Axiovision software (Carl Zeiss)

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