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Indeed, a vicious circle hypothesis has been proposed [26] , suggesting that an initial defect in ISC biogenesis leads to mitochondrial iron overload, which subsequently generates excessive ROS that oxidatively damage the few remaining intact ISCs, further exacerbating the pathology

21 (32), 1186211866 (2011) R

This clever move cuts down on oxidative stress and shields your cells from nasty hits

its inhibition attenuates ferroptotic death and suppresses epithelial-mesenchymal transition (EMT), a process implicated in airway remodeling ( 4.2 Immune cell crosstalk: amplifying the axis cycle Immune cells play a dual role in asthma, both responding to and actively promoting ferroptosis, thereby fueling a cycle of inflammation and cell death

Glutathione transporters