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RPE cells are crucial for vision, maintaining the vitality and function of photoreceptors by engulfing detached outer segments of photoreceptors (Sugita et al., 2021), and are commonly used in ophthalmic research and general epithelial cell research ( Based on the physiological structure of the retina and the characteristics of blue light induced retinal lesions, mouse retinal photoreceptor cells (661W cells) and human retinal pigment epithelial cells (ARPE-19 cells) are commonly used cell models for light damage (Figure 3)

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