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The rate of positivity increases as pernicious anemia progresses (Htut TW, 2021)

Cell death in tumor cells was quantified by multiplex immunofluorescence (mIF) using cleaved Poly (ADP-ribose) polymerase (cPARP) with pan-cytokeratin (PanCK) for tumor mask visualization, Ki67 for context, and DAPI for nuclei

2018;20:e4

A patient with glaucoma is also likely to have a visual field test to measure losses in peripheral vision and a visual acuity test to check for visual sharpness (acuity)

An independent assessment committee evaluated the endpoints and determined threshold criteria for clinically meaningful responses before the trials unblinding