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Autophagy is involved in the metabolism coupling between TME and AML Recent studies have demonstrated that cancer cells can remodel the microenvironment into a self-reinforcing tumor microenvironment (TME) to support their survival and proliferation [127, 128]

CagriSema, the combination of cagrilintide 2.4 mg and semaglutide 2.4 mg, produced an estimated mean body weight reduction of 20.4% compared to 3.0% with placebo