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The most common adverse reactions (incidence 20%) of pemetrexed, when administered in combination with pembrolizumab and platinum chemotherapy, are fatigue/asthenia, nausea, constipation, diarrhea, decreased appetite, rash, vomiting, cough, dyspnea, and pyrexia

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Second, molecules accumulating at the pole tend to be extruded through protrusions in the myeloma membrane and eventually released into biological fluids as MVs

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