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(1)(4) A study (1) was conducted where a murine model was exposed to the endogenous IGF-1 with IGF-1 LR3

158 Some studies have shown that ALDH1A1 expression is elevated and ALDH1B1 and ALDH2 expression is reduced in HCC tissues

10.1212/wnl.25.7.603 24 CarricoC.MeyerJ

Until stereoisomer-specific studies and formal pharmacovigilance data are available, any long-term or high-dose use carries unknown risk

Further, aptamers have multiple characteristics that favor their transport across BBB which can be leveraged for delivering therapeutics to the brain (Figure 5)