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For example, even if it is known that a native version of protein can be unfolded with 4 M urea, the same protein in an E

These hydrogels form a gel with mechanical properties comparable to native disc tissue within seconds to minutes

10.1016/j.phymed.2019.152860 18 CaoX.XiaoH.ZhangY.ZouL.ChuY.ChuX

Brumell J

AAV-mediated acute knockdown of Gpr146 confirms its role in promoting hepatic steatosis and adiposity To further validate the regulatory role of GPR146 in hepatic lipid accumulation and to rule out the possibility that the phenotypes observed in germline knockout mice result from developmental compensation, we employed an AAV-mediated approach to acutely knock down Gpr146 in adult mice