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None of the interventions altered sperm morphology in controldiet animals, yet all treatments, alone or combined, significantly reduced the incidence of sperm abnormalities in the AGEdiet group (Fig

AOD 9604 has shown promising beneficial patterns, such as metabolic rate and fat loss

15 HIF-1 consists of HIF-1 and HIF-1 subunits, which interact with the hypoxia-responsive element (HRE) to further modulate the expression of target genes

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Interestingly, ALS and frontotemporal dementia (FTD) are closely related conditions and often share both genetic and disease mechanisms, especially in people with C9ORF72 mutations suggesting they may be part of the same disease spectrum (Parobkova and Matej, 2021)