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Cancer cells invasively damage the body due to their infinite proliferation, loss of polarity, and decreased adhesion

This is invasive and not always accessible, leading to severe diagnostic delays estimated to be between 4 to 11 years and a massive underestimation of disease prevalence

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This disrupts various signaling pathways, including those involved in tau phosphorylation, function of synapses, and survival of neuron cells

Fu X, Feng Y, Shao B, Zhang Y (2019) Activation of the ERK/Creb/Bcl2 pathway protects periodontal ligament stem cells against hydrogen peroxide-induced oxidative stress