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YAP1 mediated the upregulation of ACSL4 through TEA domain transcription factor 1 (Tead1)/ TEA domain transcription factor 4 (Tead4)-related Hippo signaling, thus increasing LPO levels and causing ferroptosis in skeletal muscle cells (Yang et al., 2020

However, a 4-week treatment in combination with pioglitazone demonstrated an increase in body weight in both mice and reduced the food intake [16]

Similarly, in the lean adipose, microRNA-125b-5p was downregulated while its target gene phosphoglycolate phosphatase ( Pgp) was upregulated

CrossRef Large Language Models in Critical Care Medicine: Scoping Review Tongyue Shi, Jun Ma, Zihan Yu, Haowei Xu, Rongxin Yang, Minqi Xiong, Meirong Xiao, Yilin Li, Huiying Zhao, Guilan Kong JMIR Medical Informatics .2025