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Glutamine metabolism thus promotes cytokine production, including interferon- (IFN-) and IL-2, through the activation of mTORC1 and c-Myc, contributing to potent anti-tumor responses (72)

Therefore, local glutamate/glutamine dysregulation could be used as a biomarker of HIV infection, be exploited in potential treatments, and could also explain the increased susceptibility of infected individuals to several types of cancer that may also use glutamine/glutamate as a major source of energy to survive 22,94

Mean age at onset, DBS and followup were 39.410.7, 49.311.9 years, and 28.215.7 months, respectively

However, this ROS decrease did not impact the drug-related apoptosis rate

Liu Y, Guo X, Hu X, et al