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222,223 The protective effects of Klotho extend to the liver, where it contributes to the regulation of glucose and lipid metabolism and protects against liver fibrosis and steatosis

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This review summarizes the mechanism of Hcy-induced endothelial injury and the treatment methods to alleviate the Hcy induced endothelial dysfunction, in order to provide new thoughts for the diagnosis and treatment of Hcy-induced endothelial injury and subsequent AS-related diseases

[1] The human glutaminyl-tRNA synthetase structure at N-terminus contains a two tandem nonspecific RNA binding regions, a catalytic domain, and two tandem anti-codon binding domains in the C-terminus

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