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Mechanistically, it was found that HIF-1 accelerates degradation of HMG-CoA reductase in the liver through activation of insulin-induced gene two transcription, leading to reduced cholesterol synthesis (Hwang et al., 2017)

Once-weekly cagrilintide for weight management in people with overweight and obesity: A multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial