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Bao YY, et al

These changes predominantly affected pathways involved in inflammatory responses, cytokine production and macrophage activation

Perhaps two of the more significant omissions are the hypotheses that 1) more than one mutation may be required to initiate and promote cancer, and 2) not all genetic defects result in cancer

Follow-up laboratory studies demonstrated that increased serum cysteamine, decreased glutathione (GSH) and PPAR-, downstream molecules of VNN1, were also associated with PDAC-associated diabetes

The lack of multi-drug delivery platforms and long-term stability further restricts the clinical utility of PLGA nanosystems