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39Yeilda, A., et al

10.1016/j.cell.2016.02.011 77

Sequence degeneracy involves mismatches ranging from 1 to 3 base pairs per 15-mer ARE, a higher GC content in the 3 bp spacer between hexamers in imperfect AREs, and over two-thirds of AREs are recognized to consist of half sites only, with a minority making up canonical 15mer AREs [53, 56]

However, this cannot exclude the possibility of ATP synthesis defect in patients with CFS as insufficient ATP synthesis could be offset by compensatory homeostatic mechanisms