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L.YuL.HackfortB.WangH.et al

SIRT1 deacetylates nuclear factor-erythroid 2-related factor 2 (Nrf2), reducing hepatic oxidative stress and inhibiting HFD-induced MAFLD

The issue you mention is a very real side effect - however, I address it in a completely different way by substituting the .9% Bacteriostatic Saline diluent solution with a proprietary blend of a wound wash Irrigant solution comprised of NanoMetallic Silver Oxide

Across this body of work, the consistent findings are: reduced shedding within four to six weeks of consistent daily use, measurable increases in hair density at the temporal and crown regions over three to six months, and self-reported improvement in hair quality and scalp comfort that tracks with the in-vitro evidence on inflammation and oxidative stress

It's part of the broader pattern of aging that affects every regenerative process in your body