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At the molecular/physiological level, the naked mole-rat shows typical age-related decline, e.g., in activity levels, skin structure (Buffenstein and Jarvis, 2002), liver detoxification pathways (Heinze et al., 2018), lesion and lipofuscin accumulation in various organs (Edrey et al., 2011)

S4), indicating its role in iron inter-tissue trafficking

Co-localization with RNA-polymerase II and binding to chromatin, as shown by co-precipitation with histone H3, further support a transcriptional regulation role for IGF-1R [88,89]

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Soeters PB, van de Poll MC, van Gemert WG, Dejong CH