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Besides antagonizing IGF-1R, IGF-2R promotes the transport of lysosomal enzymes and the tumor suppressor TGF-1 into cells to exert inhibitory effects on tumor development

These findings indicate that limiting serine metabolism may have significant implications for immunotherapy, highlighting the importance of targeting these pathways in cancer therapy

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This intracellular iron overload is linked to dysregulated expression of key iron-related proteins such as DMT1, TfR1, ferritin, and ferroportin (FPN), which regulate iron influx, storage, and efflux (352, 353, 355, 362)