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However, this does not mean eating watermelon can replace current medical treatments

Mechanism well-characterized in dermal fibroblasts

[5] More Effective at Raising Arginine Levels - Studies show that L-citrulline supplementation increases plasma L-arginine concentrations more effectively than an equivalent dose of L-arginine itself

Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle

Preclinical evidence shows the significance of microbial metabolites and immune signaling in driving these effects, and recent clinical studies further supports these findings (Touchefeu et al., 2014