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Thiopurines Around 60% of patients with IBD receive oral thiopurines (e.g

Kijima et al, 2003

Lopresti AL, Smith SJ, Rea A, Michel S

The pathological hallmarks of AD include extracellular amyloid plaques formed by aggregation of A oligomers into A plaques and intracellular NFT caused by hyperphosphorylated tau, both of which gradually accumulate in the brain over several years

Additionally, exposure to ROS can lead to modifications that cause genomic DNA mutations, negatively affect protein activity, damage cellular membranes, and eventually leading to cell death