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Long term treatment with metformin significantly reduced transaminase concentrations and liver size.44 Thiazolidinediones have been shown to improve insulin sensitivity in patients with type 2 diabetes, they decrease serum aminotransferase levels, decrease liver fat, and improve the histological features of steatohepatitis (steatosis, ballooning necrosis, and centrilobular inflammation).45 The control of serum glucose and lipids levels should be part of the management

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Then behavioral outcomes were assessed, while molecular analyses quantified reduced, oxidized, and total glutathione in peripheral blood mononuclear cells (PBMCs)