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This discovery was swiftly confirmed in humans, establishing reserpine-treated rodents, as a reliable method to evaluate the potential symptomatic benefits of new drugs for PD (Degkwitz et al

In addition, doxorubicin was applied in multiple dosages (3 mg/kg s.c., once weekly through 13 weeks) and in single dosages (7 mg/kg, i.v.) and provoked cardiomyopathy