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10.1038/327117a0 [DOI] [PubMed] [Google Scholar] Arrang J

The lower-body program consisted of leg press, back extension, step up, leg curl, leg extension, heel raise, and abdominal crunch exercises, also performed twice per week

Using in silico design, structureactivity relationships (SARs), chemical optimization, cell-based assays and in vivo experiments, we identified and characterized the first-in-kind small-molecule inhibitors of STX7Munc13-4-dependent endosomal maturation and signaling for use in immune cells that contribute to systemic inflammation

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Mitochondrial ATP-synthase as a key lipoxidation target