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A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-talk with EGFR and HER-3

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Overexpression of miRNA-195 observed in T1DM and T2DM hearts may contribute to downregulation of SIRT1 in these hearts, and impaired SIRT1 activity can then be assumed to downregulate oxidative metabolism, mitochondrial function and to increase ROS production [133]

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Mechanisms for the induction of oxidative stress by interaction with the cell thiolome will be presented, based on literature evidence and of experimental findings

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