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Oxidative stress also contributes to PD, and conventional treatments (NSAIDs, hormonal contraceptives) may be ineffective or cause adverse effects (Oladosu et al., 2018

Signalling, inflammation and arthritis: NF-kappaB and its relevance to arthritis and inflammation

Kovacs, K

AOCDs are frequently associated with the same genes that determine PFIC, but while in PFIC these genes behave as recessive, in adult cholestasis, they can behave as autosomal dominant, being often in the heterozygous state [22]

Franks JM, Martyanov V, Wang Y, Wood TA, Pinckney A, Crofford LJ, Keyes-Elstein L, Furst DE, Goldmuntz E, Mayes MD, McSweeney P, Nash RA, Sullivan KM, Whitfield ML (2020) Machine learning predicts stem cell transplant response in severe scleroderma