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Dixit, K

Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension

This gene inhibits ferroptosis and is implicated in neurological disorders by modulating iron-regulated proteins such as transferrin, thus maintaining iron homeostasis within cellular iron pools (Ryan et al., 2023)

This process subsequently triggers lipid peroxidation and ferroptosis, events that cumulatively attenuate the antitumor immune response and reduce the efficacy of immunotherapy