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Reduced CII activity has consequences for central carbon metabolism because CII is involved in the conversion of succinate to fumarate within the TCA cycle 73

additionally NAD + can be generated in the mitochondria from NMNAT3 80 , whose activity has been shown to be required in cells 77 , but dispensable in vivo as NAD + can be replenished through other pathways such as import from the cytosol 81

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doi: 10.1007/s12602-025-10512-7 162 KoiralaRGargariGArioliSTavernitiVFioreWGrossiEet al

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