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A diminished response of astrocytes with C9orf72 hexanucleotide repeat expansion provided a link of dysregulated ligandreceptor pairs in microglia and astrocytes (Masrori et al., 2025)

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GHK binds copper with exceptionally high affinity, forming a stable square-planar complex (GHK-Cu) that is the biologically active form responsible for the peptides regenerative effects