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Keep in mind that MTHFR variants are common: My final point is that the MTHFR C677T and A1298C variants are very common

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Diet-induced obese animals exhibit indices of altered central monoaminergic neurotransmission, including reduced hypothalamic 1 adrenoceptor binding, enhanced electrophysiological responsiveness to norepinephrine application, decreased basal hypothalamic serotonin and dopamine levels, and reduced mesolimbic dopamine activity

Footnotes Declaration of Conflicting Interests: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Dr Sciubba is a consultant for Medtronic, Depuy-Synthes, Stryker, Nuvasive, and K2M

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