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It is interesting to note that resveratrol has been observed to increase the mRNA levels of Egr3 and Sirt1 in the amygdala (Hidema et al., [92]), while aspirin treatment has been observed to increase the expression of p-ACC and p-AMPK in the hippocampus [97]

Many of these sites consist of contiguous short stretches of amino acid sequences that overlap between neighboring peptides with binding activity which are used to tentatively determine major binding motifs