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doi: 10.1073/pnas.1102999108 [DOI] [PMC free article] [PubMed] [Google Scholar] 192

Muguerza B, Castilla-Cortzar I, Garca M et al (2001b) Antifibrogenic effect in vivo of low doses of insulin-like growth factor-I in cirrhotic rats

Current research focuses on counteracting HO-1-mediated ferroptosis through the following strategies: using HO-1 inhibitors (e.g., zinc protoporphyrin-IX (ZnPP)), ferroptosis inhibitors (e.g., ferrostatin-1, iron chelators), modulating key signaling pathways (e.g., targeting the Nrf2/Keap1 axis), and microRNA-mediated inhibition (e.g., miR-24, miR-200c) (69)

10.1016/j.freeradbiomed.2021.08.243 13

Ornithine is further metabolized by ornithine aminotransferase and ornithine decarboxylase to proline and polyamines, respectively