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Igaz LM, Kwong LK, Lee EB, Chen-Plotkin A, Swanson E, Unger T, Malunda J, Xu Y, Winton MJ, Trojanowski JQ, Lee VM-Y (2011) Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice

Particularly, swimming-based protocol resulted in a remarkable increase in the lifespan and neuroprotection, associated with changes in skeletal muscle energetic metabolism, leading to energetic fuel shifts toward glucose ( Overall, endurance training with a supplemental support such as ventilation or weight support seems to have positive effects on respiratory capacity, functionality, and physical performance in ALS patients, but further studies investigating the therapeutic benefits of exercise with a larger number of participants are needed to confirm these findings

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