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For instance, mutation of TTLL1 causes male infertility, massive defects in the assembly of the sperm flagellum, defects in the function of the nasal (Vogel et al, 2010), and airway ciliated epithelia (Ikegami et al, 2010)

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Therefore, it is crucial to determine the dynamics, quantity, size, and morphology of -H2AX-related foci to distinguish them from actual DNA damage