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The human OCTN1 (SLC22A4) reconstituted in liposomes catalyzes acetylcholine transport which is defective in the mutant L503F associated to the Crohns disease

CT2 is also involved in the intracellular accumulation of bleomycin in human testicular cancer cells, which are sensitive to this drug (Table 1)

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It has been shown to have a role to play in enhancing endothelial nitric oxide synthase to produce more NO from L-arginine, which also forms the rationale behind combining the two